Revolutionizing drug discovery at the intersection of semiconductors, live-cell biology and machine learning
Semiconductor-Bio Measurement and Manipulation Platform
By putting consumer-grade CMOS chips directly into each well of a cell-culture microplate, we enable real-time, live cell electrochemical imaging of cell cultures and novel in-vitro screens. Screening biological parameters never before available, opening up opportunities to generate a unique drug discovery pipeline. Quantifying morphological parameters like adhesion and attachment which have direct relevance to inflammation and cystic diseases. Measuring metabolic state, apoptosis/necrosis for cancer applications and electrical parameters for cardiovascular or neurological diseases.
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LABEL-FREE KINETICSThe growth of the cell sheet can be measured to gather confluency over time
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CELL MANIPULATIONCreate customized wound healing assays or form repeatable co-cultures
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BARRIER FUNCTIONPerform spatial TEER measurements to accurately assess cell-cell junction integrity
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REDOX METABOLISMVisualize metabolic state of cells, investigate oxidative stress, antioxidant capacity, or mechanism of cell-death
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ELECTROPHYSIOLOGYMeasure & stimulate the electrical signals of excitable cells such as cardiomyocytes or neurons
Multi-Parametric
Combining cell kinetics, barrier function, metabolic state, electrophysiology measurements and manipulations from the same cell culture
Live-Cell
Delivering non-invasive and label free measurements through the whole duration of the assay – quality data extracted from living cells as they culture
High-Resolution
Generating optics-free images to understand what is happening down to a single cell – overcome traditional whole-well aggregate readouts
CytoTronics’ high-dimensional and functional assessment of live-cells
News and Publications
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CDL Computational BiologyCDL is a non-profit organization with advisors and mentors assigned to massively-scalable, early-stage, technology-based companies.
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Funding Announced (2022)CytoTronics Launches with $9.25 Million in Seed Funding to Revolutionize Drug Discovery and Phenotypic Screening.
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Lab on a Chip (2022)Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array.
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Nature Biomedical Engineering (2020)A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons.
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IEEE Journal of Solid-State Circuits (2020)CMOS nanoelectrode array for intracellular recording and stimulation of mammalian neurons.
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Nature Nanotech (2017)
Our Team
CytoTronics is a tech-bio startup spun out from a multi-disciplinary research project from three Labs at Harvard University spanning semiconductor design, chemistry and systems biology.
We are building a drug discovery engine based on a platform technology that uses a proprietary semiconductor-bio interface to generate unique cell-biology information.
Our platform allows us to screen parameters that were impossible before, opening up opportunities to generate a unique drug discovery pipeline.
OPERATING TEAM
BOARD OF DIRECTORS
ADVISORS
OPERATING TEAM
Alexander Alexeyev
Head of Electrical Engineering
Lori Cirella
Finance Manager
Lori Cirella
Finance Manager
Bert Lannon, PhD
Snr Biologist & Data Scientist
Brendan Powers
Principal Software Engineer
Hollin Wilkins
Principal Cloud Software Engineer
BOARD OF DIRECTORS
Douglas Kahn
Executive Chariman, CytoTronics
Former CEO & Chairman, TetraGenetics (acquired by AbCellera)
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Douglas Kahn
Executive Chairman, CytoTronics
Former CEO & Chairman, TetraGenetics (acquired by AbCellera)
Tayo Sanders, PhD
Observer, Director at SR Venture Studio
ADVISORS
Scientific Co-Founders
Donhee Ham, PhD
Harvard Professor of Electrical Engineering & Applied Physics
Hongkun Park, PhD
Harvard Professor of Physics & Chemistry
Advisors
Milad Alucozai
Head of Bio and Deep Tech, BoxOne Ventures
Chris Brown, PhD
Co-founder and CTO, 908 Devices
William Cantley, PhD
Senior Scientist, CNS Biology, Alnylam Pharmaceuticals
Mike Cuccarese, PhD
Director Translational Oncology, Recursion
Keith James, PhD
Retired – former SVP Drug Discovery Insitro, prior roles with Ferring Pharmaceuticals and Pfizer
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Keith James, PhD
Retired – former SVP Drug Discovery Insitro, prior roles with Ferring Pharmaceuticals and Pfizer
Lincoln Muir
Retired – former ACEA Biosciences (Agilent Technologies) Director
Vladislav Zarayskiy, PhD
Monte Rosa Therapeutics
Collaborators
Avik Mukherjee, PhD
Postdoctoral Researcher, Harvard Medical School
Markus Basan, PhD
Assistant Professor, Harvard Medical School