Revolutionizing drug discovery at the intersection of semiconductors, live-cell biology and machine learning

Semiconductor-Bio Measurement and Manipulation Platform

By putting consumer-grade CMOS chips directly into each well of a cell-culture microplate, we enable real-time, live cell electrochemical imaging of cell cultures and novel in-vitro screens. Screening biological parameters never before available, opening up opportunities to generate a unique drug discovery pipeline. Quantifying morphological parameters like adhesion and attachment which have direct relevance to inflammation and cystic diseases. Measuring metabolic state, apoptosis/necrosis for cancer applications and electrical parameters for cardiovascular or neurological diseases.

LABEL-FREE KINETICS

The growth of the cell sheet can be measured to gather confluency over time
CELL MANIPULATION

Create customized wound healing assays or form repeatable co-cultures
BARRIER FUNCTION

Perform spatial TEER measurements to accurately assess cell-cell junction integrity
REDOX METABOLISM

Visualize metabolic state of cells, investigate oxidative stress, antioxidant capacity, or mechanism of cell-death
ELECTROPHYSIOLOGY

Measure & stimulate the electrical signals of excitable cells such as cardiomyocytes or neurons

Multi-Parametric

Combining cell kinetics, barrier function, metabolic state, electrophysiology measurements and manipulations from the same cell culture

Live-Cell

Delivering non-invasive and label free measurements through the whole duration of the assay – quality data extracted from living cells as they culture

High-Resolution

Generating optics-free images to understand what is happening down to a single cell – overcome traditional whole-well aggregate readouts

CytoTronics’ high-dimensional and functional assessment of live-cells

News and Publications

CDL Computational Biology

CDL is a non-profit organization with advisors and mentors assigned to massively-scalable, early-stage, technology-based companies.

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Funding Announced (2022)

CytoTronics Launches with $9.25 Million in Seed Funding to Revolutionize Drug Discovery and Phenotypic Screening.

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Lab on a Chip (2022)

Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array.

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Nature Biomedical Engineering (2020)

A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons.

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IEEE Journal of Solid-State Circuits (2020)

CMOS nanoelectrode array for intracellular recording and stimulation of mammalian neurons.

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Nature Nanotech (2017)

CMOS nanoelectrode array for all-electrical intracellular electrophysiological imaging.

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Our Team

CytoTronics is a tech-bio startup spun out from a multi-disciplinary research project from three Labs at Harvard University spanning semiconductor design, chemistry and systems biology.

We are building a drug discovery engine based on a platform technology that uses a proprietary semiconductor-bio interface to generate unique cell-biology information.

Our platform allows us to screen parameters that were impossible before, opening up opportunities to generate a unique drug discovery pipeline.

OPERATING TEAM

BOARD OF DIRECTORS

ADVISORS

OPERATING TEAM

BOARD OF DIRECTORS

ADVISORS

Careers

Current Openings

Senior Biologist

Resume Drop for Future Opportunities

Don’t see your perfect role, but interested in developing a breakthrough technology targeting immediate drug discovery applications? We don’t want to let a job description stop you from applying and are always looking for high performers to join our team.

Revolutionizing drug discovery at the intersection of semiconductors, live-cell biology and machine learning

Semiconductor-Bio Measurement and Manipulation Platform

Multi-Parametric

Live-Cell

High-Resolution

CytoTronics’ high-dimensional and functional assessment of live-cells

News and Publications

Our Team

CytoTronics is a tech-bio startup spun out from a multi-disciplinary research project from three Labs at Harvard University spanning semiconductor design, chemistry and systems biology.

We are building a drug discovery engine based on a platform technology that uses a proprietary semiconductor-bio interface to generate unique cell-biology information.

Our platform allows us to screen parameters that were impossible before, opening up opportunities to generate a unique drug discovery pipeline.

Jeffrey Abbott, PhD

Alexander Alexeyev

Zach Boynton

Mickey Cheah

Shalaka Chitale, PhD

Lori Cirella

Michele Giovenelli

Bert Lannon, PhD

Hendrick Melo

Ishan Nag

Brendan Powers

Duane Sword

Hollin Wilkins

Vince Wu, PhD

Jeffrey Abbott, PhD

Jenna Abelli

Douglas Kahn

Tayo Sanders, PhD

Duane Sword

Vince Wu, PhD

Scientific Co-Founders

Donhee Ham, PhD

Hongkun Park, PhD

Advisors

Milad Alucozai

Chris Brown, PhD

William Cantley, PhD

Mike Cuccarese, PhD

Keith James, PhD

Lincoln Muir

Vladislav Zarayskiy, PhD​

Collaborators

Avik Mukherjee, PhD

Markus Basan, PhD

Careers

Current Openings

Resume Drop for Future Opportunities

Don’t see your perfect role, but interested in developing a breakthrough technology targeting immediate drug discovery applications? We don’t want to let a job description stop you from applying and are always looking for high performers to join our team.

Careers

RESUME DROP FOR FUTURE OPPORTUNITIES

Don’t see your perfect role, but interested in developing a breakthrough technology targeting immediate drug discovery applications? We don’t want to let a job description stop you from applying and are always looking for high performers to join our team.

JOIN OUR MAILING LIST

At the heart of Boston's south end at AgilityLabs, CytoTronics is proximate to highways 93 & 90, the Broadway red-line T-stop, downtown Boston, & the Seaport district.

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Vladislav Zarayskiy, PhD