Drug Screening at Semiconductor Scale
Real-time, high resolution, live-cell assays using our electronic platform
Semiconductor-Bio Measurement and Manipulation Platform
By putting consumer-grade CMOS chips directly into each well of a cell-culture microplate, we enable real-time, live cell electrochemical imaging of cell cultures and novel in-vitro screens. Screening biological parameters never before available, opening up opportunities to generate a unique drug discovery pipeline. Quantifying morphological parameters like adhesion and attachment which have direct relevance to inflammation and cystic diseases. Measuring metabolic state, apoptosis/necrosis for cancer applications and electrical parameters for cardiovascular or neurological diseases.
LABEL-FREE KINETICSThe growth of the cell sheet can be measured to gather confluency over time
CELL MANIPULATIONCreate customized wound healing assays or form repeatable co-cultures
BARRIER FUNCTIONPerform spatial TEER measurements to accurately assess cell-cell junction integrity
REDOX METABOLISMVisualize metabolic state of cells, investigate oxidative stress, antioxidant capacity, or mechanism of cell-death
ELECTROPHYSIOLOGYMeasure & stimulate the electrical signals of excitable cells such as cardiomyocytes or neurons
Combining cell kinetics, barrier function, metabolic state, electrophysiology measurements and manipulations from the same cell culture
Delivering non-invasive and label free measurements through the whole duration of the assay – quality data extracted from living cells as they culture
Generating optics-free images to understand what is happening down to a single cell – overcome traditional whole-well aggregate readouts
Changing the way the world looks at cells – CytoTronics’ cell manipulation & measurement platform
News and Publications
CDL Computational BiologyCDL is a non-profit organization with advisors and mentors assigned to massively-scalable, early-stage, technology-based companies.
Funding Announced (2022)CytoTronics Launches with $9.25 Million in Seed Funding to Revolutionize Drug Discovery and Phenotypic Screening.
Lab on a Chip (2022)Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array.
Nature Biomedical Engineering (2020)A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons.
IEEE Journal of Solid-State Circuits (2020)CMOS nanoelectrode array for intracellular recording and stimulation of mammalian neurons.
Nature Nanotech (2017)CMOS nanoelectrode array for all-electrical intracellular electrophysiological imaging.
CytoTronics is a tech-bio startup spun out from a multi-disciplinary research project from three Labs at Harvard University spanning semiconductor design, chemistry and systems biology.
We are building a drug discovery engine based on a platform technology that uses a proprietary semiconductor-bio interface to generate unique cell-biology information.
Our platform allows us to screen parameters that were impossible before, opening up opportunities to generate a unique drug discovery pipeline.
BOARD OF DIRECTORS
Jeffrey Abbott, PhD
Co-founder & CEO
Head of Electrical Engineering
Zach Boynton, PhD
ASIC Design Engineer
Senior ASIC Design Engineer
Shalaka Chitale, PhD
Bert Lannon, PhD
Snr Biologist & Data Scientist
VP, Software Development
Principal Software Engineer
Co-founder & CBO
Principal Cloud Software Engineer
Vince Wu, PhD
Co-founder & CTO
BOARD OF DIRECTORS