Studying cardiac function and structure at the cellular level is necessary for modeling cardiovascular conditions, as well as screening drugs for cardiotoxicity. This requires integrated analysis of electrical activity, contractility, and morphology, which remains challenging and expensive with traditional methodologies.
In this technical note, you will explore:
- How CytoTronics’ Pixel™ system simultaneously captures cardiomyocyte electrophysiology, contractility, and morphology features in real time
- Multi-modal data from co-cultures of cardiomyocytes and fibroblasts modeling cardiac tissue
- Pharmacological validation of readouts with reference compounds that modulate various parameters of cardiac function and structure
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Effects of isoproterenol on beat rate (A) and dofetilide on field potential duration (B).
