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At the core of the Pixel system is a proprietary microplate embedded with custom-designed semiconductor microchips at the base, providing thousands of measurement and stimulation electrodes in each well. The electrodes can monitor cell viability, morphology, electrophysiology, metabolism, and more while generating electrical images of single-cell spatial resolution. The system is designed for ease of use by enabling plating of any cell type with a wide range of biological coatings.